FDA has issued a final guidance entitled Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System. The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis of their solubility and permeability. [1] This system restricts the prediction using the parameters solubility and intestinal permeability.

1. Bcs Ii

The Role of BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in Drug Development. For an orally administered drug to be ≥90% metabolized by Phase I oxidative and Phase II conjugative process it is obvious that the drug must be absorbed.”.

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Bcs Ii

For orthopaedic surgeons seeking treatment solutions beyond traditional knee replacements, JOURNEY ◊ II Bi-Cruciate Stabilized has been engineered to empower patients with a renewed right to an active lifestyle by breaking through traditional knee replacement barriers and delivers unmatched Function, Motion and Durability through PHYSIOLOGICAL MATCHING Technology. JOURNEY II Bi-Cruciate Stabilized (BCS) Total Knee System Function: Stability – Provides a proper femoro-tibial A/P position yielding a virtual elimination of paradoxical motion, anterior sliding of the femur during flexion. 1-8 Strength – Restoration of both the anatomic A/P alignment and the normal kinematic patterns of the knee may produce more normal neuromuscular firing patterns throughout the range of motion as demonstrated in the original BCS design. 5-10 Satisfaction – Restoration of more normal neuromuscular firing patterns throughout the range of motion may improve a patient’s ability to perform the activities they are demanding as demonstrated in the original BCS design.

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